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An in vitro stem cell expansion device (also called a bioreactor) that mimics the desired cell environment to promote stem cell expansion while preserving self-renewal and multipotent properties was developed at Southwest Research Institute (SwRI). To mimic the in vivo cell environment, we use a three-dimensional (3D) collagen scaffold that has open-cell interconnected porous network that resembles the desired tissue with a specialized circulation system, including controlled fluid flow, nutrition supply, gas (O2, CO2) concentration, and temperature conditions similar to the tissue environment. While SwRI is currently using the bioreactor for bone applications, the technology can be modified for the development of other tissue-specific bioreactors, such as bioreactors for cartilage, muscle, blood vessels, etc.
For more information about the biomaterials capabilities at SwRI or how you can contract with us, please contact Jian Ling, Ph.D., at jling@swri.org or (210) 522-3953.
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Southwest Research Institute® (SwRI®), headquartered in San Antonio, Texas, is a multidisciplinary, independent, nonprofit, applied engineering and physical sciences research and development organization with 11 technical divisions. |
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June 16, 2011 |
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